Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Plasmodium falciparum (isolate K1 / Thailand)) | BDBM50138689
(5-{3-Methoxy-4-[3-(3-phenoxy-propoxy)-propoxy]-ben...)Show InChI InChI=1S/C24H30N4O4/c1-29-22-16-18(15-19-17-27-24(26)28-23(19)25)9-10-21(22)32-14-6-12-30-11-5-13-31-20-7-3-2-4-8-20/h2-4,7-10,16-17H,5-6,11-15H2,1H3,(H4,25,26,27,28) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
| Assay Description Inhibitory activity against wild-type dihydrofolate reductase (S108N DHFR) |
J Med Chem 47: 345-54 (2004)
Article DOI: 10.1021/jm0303352 BindingDB Entry DOI: 10.7270/Q237784Q |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Plasmodium falciparum (isolate K1 / Thailand)) | BDBM50138689
(5-{3-Methoxy-4-[3-(3-phenoxy-propoxy)-propoxy]-ben...)Show InChI InChI=1S/C24H30N4O4/c1-29-22-16-18(15-19-17-27-24(26)28-23(19)25)9-10-21(22)32-14-6-12-30-11-5-13-31-20-7-3-2-4-8-20/h2-4,7-10,16-17H,5-6,11-15H2,1H3,(H4,25,26,27,28) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 154 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
| Assay Description Inhibitory activity against double mutant dihydrofolate reductase (C59R+S108N DHFR) |
J Med Chem 47: 345-54 (2004)
Article DOI: 10.1021/jm0303352 BindingDB Entry DOI: 10.7270/Q237784Q |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Plasmodium falciparum (isolate K1 / Thailand)) | BDBM50138689
(5-{3-Methoxy-4-[3-(3-phenoxy-propoxy)-propoxy]-ben...)Show InChI InChI=1S/C24H30N4O4/c1-29-22-16-18(15-19-17-27-24(26)28-23(19)25)9-10-21(22)32-14-6-12-30-11-5-13-31-20-7-3-2-4-8-20/h2-4,7-10,16-17H,5-6,11-15H2,1H3,(H4,25,26,27,28) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 425 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
| Assay Description Inhibitory activity against triple mutant dihydrofolate reductase (C59R S108 NI164L DHFR) |
J Med Chem 47: 345-54 (2004)
Article DOI: 10.1021/jm0303352 BindingDB Entry DOI: 10.7270/Q237784Q |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Plasmodium falciparum (isolate K1 / Thailand)) | BDBM50138689
(5-{3-Methoxy-4-[3-(3-phenoxy-propoxy)-propoxy]-ben...)Show InChI InChI=1S/C24H30N4O4/c1-29-22-16-18(15-19-17-27-24(26)28-23(19)25)9-10-21(22)32-14-6-12-30-11-5-13-31-20-7-3-2-4-8-20/h2-4,7-10,16-17H,5-6,11-15H2,1H3,(H4,25,26,27,28) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
| Assay Description Inhibitory activity against quadruple mutant dihydrofolate reductase (N51I C59R S108N I164L DHFR) |
J Med Chem 47: 345-54 (2004)
Article DOI: 10.1021/jm0303352 BindingDB Entry DOI: 10.7270/Q237784Q |
More data for this Ligand-Target Pair | |