Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50363256
(CHEMBL1947001)Show SMILES COc1cc(N2CCN(C)CC2)c2cc1[nH]c1ncc(Cl)c(n1)[nH]c1cc(ccc1N(C)S(C)(=O)=O)cc2 Show InChI InChI=1S/C26H30ClN7O3S/c1-32-9-11-34(12-10-32)23-15-24(37-3)21-14-18(23)7-5-17-6-8-22(33(2)38(4,35)36)20(13-17)29-25-19(27)16-28-26(30-21)31-25/h5-8,13-16H,9-12H2,1-4H3,(H2,28,29,30,31)/b7-5- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of baculovirus expressed GST-tagged human ALK cytoplasmic domain using PLCgamma as substrate after 15 mins by time-resolved fluorescence a... |
J Med Chem 55: 449-64 (2012)
Article DOI: 10.1021/jm201333e
BindingDB Entry DOI: 10.7270/Q2BP0370 |
More data for this
Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50363256
(CHEMBL1947001)Show SMILES COc1cc(N2CCN(C)CC2)c2cc1[nH]c1ncc(Cl)c(n1)[nH]c1cc(ccc1N(C)S(C)(=O)=O)cc2 Show InChI InChI=1S/C26H30ClN7O3S/c1-32-9-11-34(12-10-32)23-15-24(37-3)21-14-18(23)7-5-17-6-8-22(33(2)38(4,35)36)20(13-17)29-25-19(27)16-28-26(30-21)31-25/h5-8,13-16H,9-12H2,1-4H3,(H2,28,29,30,31)/b7-5- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of NPM-ALK autophosphorylation in human ALCL SUP-M2 cells after 2 to 3 hrs by sandwich ELISA |
J Med Chem 55: 449-64 (2012)
Article DOI: 10.1021/jm201333e
BindingDB Entry DOI: 10.7270/Q2BP0370 |
More data for this
Ligand-Target Pair | |