Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM50383310
(BUCHENAVIANINE)Show SMILES COc1cc(O)c(C2CCCCN2C)c2oc(cc(=O)c12)-c1ccccc1 Show InChI InChI=1S/C22H23NO4/c1-23-11-7-6-10-15(23)20-16(24)13-19(26-2)21-17(25)12-18(27-22(20)21)14-8-4-3-5-9-14/h3-5,8-9,12-13,15,24H,6-7,10-11H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Chimie des Substances Naturelles (ICSN)
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK5/p25 using [gamma 33P]ATP after 30 mins by scintillation counting |
J Med Chem 55: 2811-9 (2012)
Article DOI: 10.1021/jm201727w BindingDB Entry DOI: 10.7270/Q29W0GHW |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT) | BDBM50383310
(BUCHENAVIANINE)Show SMILES COc1cc(O)c(C2CCCCN2C)c2oc(cc(=O)c12)-c1ccccc1 Show InChI InChI=1S/C22H23NO4/c1-23-11-7-6-10-15(23)20-16(24)13-19(26-2)21-17(25)12-18(27-22(20)21)14-8-4-3-5-9-14/h3-5,8-9,12-13,15,24H,6-7,10-11H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Chimie des Substances Naturelles (ICSN)
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged rat recombinant DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate |
J Med Chem 55: 2811-9 (2012)
Article DOI: 10.1021/jm201727w BindingDB Entry DOI: 10.7270/Q29W0GHW |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Mus musculus) | BDBM50383310
(BUCHENAVIANINE)Show SMILES COc1cc(O)c(C2CCCCN2C)c2oc(cc(=O)c12)-c1ccccc1 Show InChI InChI=1S/C22H23NO4/c1-23-11-7-6-10-15(23)20-16(24)13-19(26-2)21-17(25)12-18(27-22(20)21)14-8-4-3-5-9-14/h3-5,8-9,12-13,15,24H,6-7,10-11H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Chimie des Substances Naturelles (ICSN)
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate |
J Med Chem 55: 2811-9 (2012)
Article DOI: 10.1021/jm201727w BindingDB Entry DOI: 10.7270/Q29W0GHW |
More data for this Ligand-Target Pair | |