Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 508.9 BDBM177029

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Maternal embryonic leucine zipper kinase (Homo sapiens (Human))	BDBM177029 (US9120749, 395) Show SMILES COc1cc(cc(Cl)c1O)-c1ccc2ncc(C(=O)C3CC3)c(NCC(=O)N3CCN(C)CC3)c2c1 Show InChI InChI=1S/C27H29ClN4O4/c1-31-7-9-32(10-8-31)24(33)15-30-25-19-11-17(18-12-21(28)27(35)23(13-18)36-2)5-6-22(19)29-14-20(25)26(34)16-3-4-16/h5-6,11-14,16,35H,3-4,7-10,15H2,1-2H3,(H,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.4	25
ONCOTHERAPY SCIENCE, INC. US Patent					Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...				US Patent US9120749 (2015) BindingDB Entry DOI: 10.7270/Q2FX7872
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