Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 531.0 BDBM177137

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Maternal embryonic leucine zipper kinase (Homo sapiens (Human))	BDBM177137 (US9120749, 503) Show SMILES COc1cc(cc(Cl)c1O)-c1ccc2ncc(C(=O)C3CC3)c(Nc3cnc(nc3)N3CCNCC3)c2c1 Show InChI InChI=1S/C28H27ClN6O3/c1-38-24-12-18(11-22(29)27(24)37)17-4-5-23-20(10-17)25(21(15-31-23)26(36)16-2-3-16)34-19-13-32-28(33-14-19)35-8-6-30-7-9-35/h4-5,10-16,30,37H,2-3,6-9H2,1H3,(H,31,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	7.4	25
ONCOTHERAPY SCIENCE, INC. US Patent					Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...				US Patent US9120749 (2015) BindingDB Entry DOI: 10.7270/Q2FX7872
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