Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 518.0 BDBM177322

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Maternal embryonic leucine zipper kinase (Homo sapiens (Human))	BDBM177322 (US9120749, 688) Show SMILES COc1cc(cc(Cl)c1O)-c1ccc2ncc(C(C)=O)c(Nc3ccc(nc3)N3CCCC(N)C3)c2c1 Show InChI InChI=1S/C28H28ClN5O3/c1-16(35)22-14-31-24-7-5-17(18-11-23(29)28(36)25(12-18)37-2)10-21(24)27(22)33-20-6-8-26(32-13-20)34-9-3-4-19(30)15-34/h5-8,10-14,19,36H,3-4,9,15,30H2,1-2H3,(H,31,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.4	25
ONCOTHERAPY SCIENCE, INC. US Patent					Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...				US Patent US9120749 (2015) BindingDB Entry DOI: 10.7270/Q2FX7872
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