Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-X-C chemokine receptor type 3/Guanine nucleotide-binding protein subunit alpha-15
(Homo sapiens (Human)) | BDBM208694
(US9266876, 161)Show SMILES COc1cc2nc([nH]c2cc1OC)-c1nc(sc1N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12)C(F)(F)F Show InChI InChI=1S/C26H25F3N8O3S/c1-14-11-35(7-8-37(14)20(38)12-36-13-31-15-5-4-6-30-23(15)36)24-21(34-25(41-24)26(27,28)29)22-32-16-9-18(39-2)19(40-3)10-17(16)33-22/h4-6,9-10,13-14H,7-8,11-12H2,1-3H3,(H,32,33)/t14-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the... |
US Patent US9266876 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80NB |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208694
(US9266876, 161)Show SMILES COc1cc2nc([nH]c2cc1OC)-c1nc(sc1N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12)C(F)(F)F Show InChI InChI=1S/C26H25F3N8O3S/c1-14-11-35(7-8-37(14)20(38)12-36-13-31-15-5-4-6-30-23(15)36)24-21(34-25(41-24)26(27,28)29)22-32-16-9-18(39-2)19(40-3)10-17(16)33-22/h4-6,9-10,13-14H,7-8,11-12H2,1-3H3,(H,32,33)/t14-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00676
BindingDB Entry DOI: 10.7270/Q2222ZSK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208694
(US9266876, 161)Show SMILES COc1cc2nc([nH]c2cc1OC)-c1nc(sc1N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12)C(F)(F)F Show InChI InChI=1S/C26H25F3N8O3S/c1-14-11-35(7-8-37(14)20(38)12-36-13-31-15-5-4-6-30-23(15)36)24-21(34-25(41-24)26(27,28)29)22-32-16-9-18(39-2)19(40-3)10-17(16)33-22/h4-6,9-10,13-14H,7-8,11-12H2,1-3H3,(H,32,33)/t14-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 144 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00676
BindingDB Entry DOI: 10.7270/Q2222ZSK |
More data for this
Ligand-Target Pair | |