Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 391.8 BDBM50190459

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Amiloride-sensitive sodium channel subunit alpha (Homo sapiens (Human))	BDBM50190459 (CHEMBL377986 | N-(3,5-diamino-6-chloropyrazine-2-c...) Show SMILES COc1ccc(CCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |w:10.9| Show InChI InChI=1S/C17H22ClN7O2/c1-27-11-7-5-10(6-8-11)4-2-3-9-22-17(21)25-16(26)12-14(19)24-15(20)13(18)23-12/h5-8H,2-4,9H2,1H3,(H4,19,20,24)(H3,21,22,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Parion Sciences Inc. Curated by ChEMBL					Assay Description Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay				J Med Chem 49: 4098-115 (2006) Article DOI: 10.1021/jm051134w BindingDB Entry DOI: 10.7270/Q2FT8KNH
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