Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM291962
(US10100019, Example 32)Show SMILES COc1ccc(CCN)cc1Nc1ncc(Cl)c(Nc2ccc(F)cc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C22H25ClFN5O3S/c1-13(2)33(30,31)20-11-15(24)5-6-17(20)27-21-16(23)12-26-22(29-21)28-18-10-14(8-9-25)4-7-19(18)32-3/h4-7,10-13H,8-9,25H2,1-3H3,(H2,26,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | 25 |
Korea Research Institute of Chemical Technology
US Patent
| Assay Description
The following experiment was performed in order to measure the activity of the N2-(2-methoxyphenyl)pyrimidine derivative represented by formula 1 of ... |
US Patent US10100019 (2018)
BindingDB Entry DOI: 10.7270/Q2125VPT |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM291962
(US10100019, Example 32)Show SMILES COc1ccc(CCN)cc1Nc1ncc(Cl)c(Nc2ccc(F)cc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C22H25ClFN5O3S/c1-13(2)33(30,31)20-11-15(24)5-6-17(20)27-21-16(23)12-26-22(29-21)28-18-10-14(8-9-25)4-7-19(18)32-3/h4-7,10-13H,8-9,25H2,1-3H3,(H2,26,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology
US Patent
| Assay Description
To measure the activity of the N2-(2-methoxyphenyl)pyrimidine derivative represented by formula 1 of the present invention to inhibit anaplastic lymp... |
US Patent US10100019 (2018)
BindingDB Entry DOI: 10.7270/Q2125VPT |
More data for this
Ligand-Target Pair | |
ALK tyrosine kinase receptor [L1196M]
(Homo sapiens (Human)) | BDBM291962
(US10100019, Example 32)Show SMILES COc1ccc(CCN)cc1Nc1ncc(Cl)c(Nc2ccc(F)cc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C22H25ClFN5O3S/c1-13(2)33(30,31)20-11-15(24)5-6-17(20)27-21-16(23)12-26-22(29-21)28-18-10-14(8-9-25)4-7-19(18)32-3/h4-7,10-13H,8-9,25H2,1-3H3,(H2,26,27,28,29) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology
US Patent
| Assay Description
To measure the activity of the N2-(2-methoxyphenyl)pyrimidine derivative represented by formula 1 of the present invention to inhibit anaplastic lymp... |
US Patent US10100019 (2018)
BindingDB Entry DOI: 10.7270/Q2125VPT |
More data for this
Ligand-Target Pair | |