Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human)) | BDBM50482138
(CHEMBL495336)Show SMILES COc1ccc(Cl)cc1Nc1nc-2c(CCCc3nc(NC(=O)C(C)(C)C)sc-23)s1 Show InChI InChI=1S/C21H23ClN4O2S2/c1-21(2,3)18(27)26-20-23-12-6-5-7-15-16(17(12)30-20)25-19(29-15)24-13-10-11(22)8-9-14(13)28-4/h8-10H,5-7H2,1-4H3,(H,24,25)(H,23,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Correction of defective trafficking of human deltaF508 mutant CFTR protein expressed in FRT epithelial cells coexpressing YFP-H148Q/I152L protein ass... |
J Med Chem 57: 6729-38 (2014)
Article DOI: 10.1021/jm5007885 BindingDB Entry DOI: 10.7270/Q2G163TK |
More data for this Ligand-Target Pair | |
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human)) | BDBM50482138
(CHEMBL495336)Show SMILES COc1ccc(Cl)cc1Nc1nc-2c(CCCc3nc(NC(=O)C(C)(C)C)sc-23)s1 Show InChI InChI=1S/C21H23ClN4O2S2/c1-21(2,3)18(27)26-20-23-12-6-5-7-15-16(17(12)30-20)25-19(29-15)24-13-10-11(22)8-9-14(13)28-4/h8-10H,5-7H2,1-4H3,(H,24,25)(H,23,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
University of Palermo
Curated by ChEMBL
| Assay Description Corrector activity at CFTR F508del mutant (unknown origin) |
Eur J Med Chem 180: 430-448 (2019)
Article DOI: 10.1016/j.ejmech.2019.07.037 BindingDB Entry DOI: 10.7270/Q2TT4VBP |
More data for this Ligand-Target Pair | |
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human)) | BDBM50482138
(CHEMBL495336)Show SMILES COc1ccc(Cl)cc1Nc1nc-2c(CCCc3nc(NC(=O)C(C)(C)C)sc-23)s1 Show InChI InChI=1S/C21H23ClN4O2S2/c1-21(2,3)18(27)26-20-23-12-6-5-7-15-16(17(12)30-20)25-19(29-15)24-13-10-11(22)8-9-14(13)28-4/h8-10H,5-7H2,1-4H3,(H,24,25)(H,23,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
University of California Davis
Curated by ChEMBL
| Assay Description Binding affinity to human CFTR F508 deletion mutant expressed in FRT cells assessed as increase in iodine influx after 16 to 20 hrs by fluorescence a... |
J Med Chem 53: 3772-81 (2010)
Article DOI: 10.1021/jm100235h BindingDB Entry DOI: 10.7270/Q2VD728K |
More data for this Ligand-Target Pair | |