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Target
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Marvin 2D Structure
The following exact ligands are found in BindingDB
Wt: 506.9
BDBM515530
Wt: 506.9
BDBM515567
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Potassium channel subfamily K member 9
(Homo sapiens (Human))
BDBM515530
((3-{[2-(4-Chlorophenyl)imidazo[1,2-a]pyrimidin-3-y...)
Show SMILES
COc1ccc(F)c(n1)C(=O)N1C2CCC1CN(Cc1c(nc3ncccn13)-c1ccc(Cl)cc1)C2 |TLB:9:11:13.14:17.35.16|
Show InChI
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
US Patent
n/a
n/a
5.20
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were conducted using stably transfected CHO cells. The compounds a...
Citation and Details
BindingDB Entry DOI:
10.7270/Q2T43X7W
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3
(Homo sapiens (Human))
BDBM515530
((3-{[2-(4-Chlorophenyl)imidazo[1,2-a]pyrimidin-3-y...)
Show SMILES
COc1ccc(F)c(n1)C(=O)N1C2CCC1CN(Cc1c(nc3ncccn13)-c1ccc(Cl)cc1)C2 |TLB:9:11:13.14:17.35.16|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
US Patent
n/a
n/a
340
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...
Citation and Details
BindingDB Entry DOI:
10.7270/Q2T43X7W
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9
(Homo sapiens (Human))
BDBM515567
(US11098063, Example 65)
Show SMILES
COc1ccc(F)c(n1)C(=O)N1C2CCC1CN(Cc1c(nc3ncccn13)-c1ccc(Cl)cc1)C2
Show InChI
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
US Patent
n/a
n/a
670
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were conducted using stably transfected CHO cells. The compounds a...
Citation and Details
BindingDB Entry DOI:
10.7270/Q2T43X7W
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3
(Homo sapiens (Human))
BDBM515567
(US11098063, Example 65)
Show SMILES
COc1ccc(F)c(n1)C(=O)N1C2CCC1CN(Cc1c(nc3ncccn13)-c1ccc(Cl)cc1)C2
Show InChI
PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
US Patent
n/a
n/a
3.50E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...
Citation and Details
BindingDB Entry DOI:
10.7270/Q2T43X7W
More data for this
Ligand-Target Pair