Found 5 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50356040
(CHEMBL1911546)Show SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cccc(c2[nH]1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C23H22F7NO2/c1-20(2,17-10-14(24)7-8-18(17)33-3)12-21(32,23(28,29)30)11-15-9-13-5-4-6-16(19(13)31-15)22(25,26)27/h4-10,31-32H,11-12H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Displacement of tetramethylrhodamine-labeled Dexamethasone from human recombinant glucocorticoid receptor expressed in baculovirus infected insect ce... |
Bioorg Med Chem Lett 21: 6842-51 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.018
BindingDB Entry DOI: 10.7270/Q2CV4J51 |
More data for this
Ligand-Target Pair | |
Mineralocorticoid receptor
(Homo sapiens (Human)) | BDBM50356040
(CHEMBL1911546)Show SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cccc(c2[nH]1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C23H22F7NO2/c1-20(2,17-10-14(24)7-8-18(17)33-3)12-21(32,23(28,29)30)11-15-9-13-5-4-6-16(19(13)31-15)22(25,26)27/h4-10,31-32H,11-12H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Displacement of tetramethylrhodamine-labeled Dexamethasone from human recombinant mineralocorticoid receptor expressed in baculovirus infected insect... |
Bioorg Med Chem Lett 21: 6842-51 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.018
BindingDB Entry DOI: 10.7270/Q2CV4J51 |
More data for this
Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50356040
(CHEMBL1911546)Show SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cccc(c2[nH]1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C23H22F7NO2/c1-20(2,17-10-14(24)7-8-18(17)33-3)12-21(32,23(28,29)30)11-15-9-13-5-4-6-16(19(13)31-15)22(25,26)27/h4-10,31-32H,11-12H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Displacement of tetramethylrhodamine-labeled RU-486 from human recombinant progesterone receptor expressed in baculovirus infected insect cells by fl... |
Bioorg Med Chem Lett 21: 6842-51 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.018
BindingDB Entry DOI: 10.7270/Q2CV4J51 |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50356040
(CHEMBL1911546)Show SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cccc(c2[nH]1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C23H22F7NO2/c1-20(2,17-10-14(24)7-8-18(17)33-3)12-21(32,23(28,29)30)11-15-9-13-5-4-6-16(19(13)31-15)22(25,26)27/h4-10,31-32H,11-12H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL1-induced IL-6 production after 18 to 24 hrs |
Bioorg Med Chem Lett 21: 6842-51 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.018
BindingDB Entry DOI: 10.7270/Q2CV4J51 |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50356040
(CHEMBL1911546)Show SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cc1cc2cccc(c2[nH]1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C23H22F7NO2/c1-20(2,17-10-14(24)7-8-18(17)33-3)12-21(32,23(28,29)30)11-15-9-13-5-4-6-16(19(13)31-15)22(25,26)27/h4-10,31-32H,11-12H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description
Transactivation activity of glucocorticoid receptor in HFF assessed as induction of aromatase activity by measuring beta-estradiol activity after 18 ... |
Bioorg Med Chem Lett 21: 6842-51 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.018
BindingDB Entry DOI: 10.7270/Q2CV4J51 |
More data for this
Ligand-Target Pair | |