Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 388.3 BDBM50201106

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50201106 (2-[(2,4-dimethylimidazol-1-yl)methyl]-1,1,1-triflu...) Show SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cn1cc(C)nc1C)C(F)(F)F Show InChI InChI=1S/C19H24F4N2O2/c1-12-9-25(13(2)24-12)11-18(26,19(21,22)23)10-17(3,4)15-8-14(20)6-7-16(15)27-5/h6-9,26H,10-11H2,1-5H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of tetramethylrhodamine labeled dexamethosone binding to MR by FP assay				J Med Chem 49: 7887-96 (2006) Article DOI: 10.1021/jm061273t BindingDB Entry DOI: 10.7270/Q2BG2PTB
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50201106 (2-[(2,4-dimethylimidazol-1-yl)methyl]-1,1,1-triflu...) Show SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cn1cc(C)nc1C)C(F)(F)F Show InChI InChI=1S/C19H24F4N2O2/c1-12-9-25(13(2)24-12)11-18(26,19(21,22)23)10-17(3,4)15-8-14(20)6-7-16(15)27-5/h6-9,26H,10-11H2,1-5H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of tetramethylrhodamine labeled dexamethosone binding to GR by FP assay				J Med Chem 49: 7887-96 (2006) Article DOI: 10.1021/jm061273t BindingDB Entry DOI: 10.7270/Q2BG2PTB
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50201106 (2-[(2,4-dimethylimidazol-1-yl)methyl]-1,1,1-triflu...) Show SMILES COc1ccc(F)cc1C(C)(C)CC(O)(Cn1cc(C)nc1C)C(F)(F)F Show InChI InChI=1S/C19H24F4N2O2/c1-12-9-25(13(2)24-12)11-18(26,19(21,22)23)10-17(3,4)15-8-14(20)6-7-16(15)27-5/h6-9,26H,10-11H2,1-5H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of tetramethylrhodamine labeled RU486 binding to PR by FP assay				J Med Chem 49: 7887-96 (2006) Article DOI: 10.1021/jm061273t BindingDB Entry DOI: 10.7270/Q2BG2PTB
					More data for this Ligand-Target Pair