Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50240534
(CHEMBL4063633)Show SMILES COc1ccc(Oc2cc(ncn2)N2CCC(CC2)C(=O)N2CCc3ccccc3C2)cc1 Show InChI InChI=1S/C26H28N4O3/c1-32-22-6-8-23(9-7-22)33-25-16-24(27-18-28-25)29-13-11-20(12-14-29)26(31)30-15-10-19-4-2-3-5-21(19)17-30/h2-9,16,18,20H,10-15,17H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human M4 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay |
Bioorg Med Chem Lett 27: 2479-2483 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.009
BindingDB Entry DOI: 10.7270/Q2VT1V7H |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50240534
(CHEMBL4063633)Show SMILES COc1ccc(Oc2cc(ncn2)N2CCC(CC2)C(=O)N2CCc3ccccc3C2)cc1 Show InChI InChI=1S/C26H28N4O3/c1-32-22-6-8-23(9-7-22)33-25-16-24(27-18-28-25)29-13-11-20(12-14-29)26(31)30-15-10-19-4-2-3-5-21(19)17-30/h2-9,16,18,20H,10-15,17H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human M4 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay |
Bioorg Med Chem Lett 27: 2479-2483 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.009
BindingDB Entry DOI: 10.7270/Q2VT1V7H |
More data for this
Ligand-Target Pair | |