Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50296880
((1-((1R,4R)-2,2-dimethyl-4-((S)-2,2,2-trifluoro-1-...)Show SMILES COc1ccc(cc1)[C@H](N[C@@H]1CC[C@@H](C(=O)N2CCC(CC2)(C(=O)N2CCCC2)c2ccccc2)C(C)(C)C1)C(F)(F)F |r| Show InChI InChI=1S/C34H44F3N3O3/c1-32(2)23-26(38-29(34(35,36)37)24-11-14-27(43-3)15-12-24)13-16-28(32)30(41)39-21-17-33(18-22-39,25-9-5-4-6-10-25)31(42)40-19-7-8-20-40/h4-6,9-12,14-15,26,28-29,38H,7-8,13,16-23H2,1-3H3/t26-,28+,29+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting |
Bioorg Med Chem Lett 19: 4781-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.050 BindingDB Entry DOI: 10.7270/Q2319VXR |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50296880
((1-((1R,4R)-2,2-dimethyl-4-((S)-2,2,2-trifluoro-1-...)Show SMILES COc1ccc(cc1)[C@H](N[C@@H]1CC[C@@H](C(=O)N2CCC(CC2)(C(=O)N2CCCC2)c2ccccc2)C(C)(C)C1)C(F)(F)F |r| Show InChI InChI=1S/C34H44F3N3O3/c1-32(2)23-26(38-29(34(35,36)37)24-11-14-27(43-3)15-12-24)13-16-28(32)30(41)39-21-17-33(18-22-39,25-9-5-4-6-10-25)31(42)40-19-7-8-20-40/h4-6,9-12,14-15,26,28-29,38H,7-8,13,16-23H2,1-3H3/t26-,28+,29+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description Displacement of [35S]MK499 from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 4781-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.050 BindingDB Entry DOI: 10.7270/Q2319VXR |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50296880
((1-((1R,4R)-2,2-dimethyl-4-((S)-2,2,2-trifluoro-1-...)Show SMILES COc1ccc(cc1)[C@H](N[C@@H]1CC[C@@H](C(=O)N2CCC(CC2)(C(=O)N2CCCC2)c2ccccc2)C(C)(C)C1)C(F)(F)F |r| Show InChI InChI=1S/C34H44F3N3O3/c1-32(2)23-26(38-29(34(35,36)37)24-11-14-27(43-3)15-12-24)13-16-28(32)30(41)39-21-17-33(18-22-39,25-9-5-4-6-10-25)31(42)40-19-7-8-20-40/h4-6,9-12,14-15,26,28-29,38H,7-8,13,16-23H2,1-3H3/t26-,28+,29+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description Displacement of [3H]imipramine from human serotonin transporter expressed in CHO cell membrane by scintillation counting |
Bioorg Med Chem Lett 19: 4781-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.050 BindingDB Entry DOI: 10.7270/Q2319VXR |
More data for this Ligand-Target Pair | |