Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human)) | BDBM50312446
(CHEMBL1081951 | {4-[4,5-Bis(4-methoxyphenyl)thiazo...)Show SMILES COc1ccc(cc1)-c1nc(SCc2ccc(OCC(O)=O)c(C)c2)sc1-c1ccc(OC)cc1 Show InChI InChI=1S/C27H25NO5S2/c1-17-14-18(4-13-23(17)33-15-24(29)30)16-34-27-28-25(19-5-9-21(31-2)10-6-19)26(35-27)20-7-11-22(32-3)12-8-20/h4-14H,15-16H2,1-3H3,(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 5.67E+3 | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description Agonist activity at human PPARdelta ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass... |
J Med Chem 53: 77-105 (2010)
Article DOI: 10.1021/jm9007399 BindingDB Entry DOI: 10.7270/Q28052RP |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50312446
(CHEMBL1081951 | {4-[4,5-Bis(4-methoxyphenyl)thiazo...)Show SMILES COc1ccc(cc1)-c1nc(SCc2ccc(OCC(O)=O)c(C)c2)sc1-c1ccc(OC)cc1 Show InChI InChI=1S/C27H25NO5S2/c1-17-14-18(4-13-23(17)33-15-24(29)30)16-34-27-28-25(19-5-9-21(31-2)10-6-19)26(35-27)20-7-11-22(32-3)12-8-20/h4-14H,15-16H2,1-3H3,(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description Agonist activity at human PPARgamma ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass... |
J Med Chem 53: 77-105 (2010)
Article DOI: 10.1021/jm9007399 BindingDB Entry DOI: 10.7270/Q28052RP |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human)) | BDBM50312446
(CHEMBL1081951 | {4-[4,5-Bis(4-methoxyphenyl)thiazo...)Show SMILES COc1ccc(cc1)-c1nc(SCc2ccc(OCC(O)=O)c(C)c2)sc1-c1ccc(OC)cc1 Show InChI InChI=1S/C27H25NO5S2/c1-17-14-18(4-13-23(17)33-15-24(29)30)16-34-27-28-25(19-5-9-21(31-2)10-6-19)26(35-27)20-7-11-22(32-3)12-8-20/h4-14H,15-16H2,1-3H3,(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description Agonist activity at human PPARalpha ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass... |
J Med Chem 53: 77-105 (2010)
Article DOI: 10.1021/jm9007399 BindingDB Entry DOI: 10.7270/Q28052RP |
More data for this Ligand-Target Pair | |