Found 8 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393811
(US10597367, Example 99 | US9969726, Example 99)Show SMILES COc1ccc(cc1OC)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C26H18F4N2O4/c1-35-21-9-7-16(12-22(21)36-2)20-13-23(26(28,29)30)32-24(31-20)17-5-3-4-14(10-17)15-6-8-19(27)18(11-15)25(33)34/h3-13H,1-2H3,(H,33,34) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393811
(US10597367, Example 99 | US9969726, Example 99)Show SMILES COc1ccc(cc1OC)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C26H18F4N2O4/c1-35-21-9-7-16(12-22(21)36-2)20-13-23(26(28,29)30)32-24(31-20)17-5-3-4-14(10-17)15-6-8-19(27)18(11-15)25(33)34/h3-13H,1-2H3,(H,33,34) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM393811
(US10597367, Example 99 | US9969726, Example 99)Show SMILES COc1ccc(cc1OC)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C26H18F4N2O4/c1-35-21-9-7-16(12-22(21)36-2)20-13-23(26(28,29)30)32-24(31-20)17-5-3-4-14(10-17)15-6-8-19(27)18(11-15)25(33)34/h3-13H,1-2H3,(H,33,34) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.83E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM393811
(US10597367, Example 99 | US9969726, Example 99)Show SMILES COc1ccc(cc1OC)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C26H18F4N2O4/c1-35-21-9-7-16(12-22(21)36-2)20-13-23(26(28,29)30)32-24(31-20)17-5-3-4-14(10-17)15-6-8-19(27)18(11-15)25(33)34/h3-13H,1-2H3,(H,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.48E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393811
(US10597367, Example 99 | US9969726, Example 99)Show SMILES COc1ccc(cc1OC)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C26H18F4N2O4/c1-35-21-9-7-16(12-22(21)36-2)20-13-23(26(28,29)30)32-24(31-20)17-5-3-4-14(10-17)15-6-8-19(27)18(11-15)25(33)34/h3-13H,1-2H3,(H,33,34) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393811
(US10597367, Example 99 | US9969726, Example 99)Show SMILES COc1ccc(cc1OC)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C26H18F4N2O4/c1-35-21-9-7-16(12-22(21)36-2)20-13-23(26(28,29)30)32-24(31-20)17-5-3-4-14(10-17)15-6-8-19(27)18(11-15)25(33)34/h3-13H,1-2H3,(H,33,34) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM393811
(US10597367, Example 99 | US9969726, Example 99)Show SMILES COc1ccc(cc1OC)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C26H18F4N2O4/c1-35-21-9-7-16(12-22(21)36-2)20-13-23(26(28,29)30)32-24(31-20)17-5-3-4-14(10-17)15-6-8-19(27)18(11-15)25(33)34/h3-13H,1-2H3,(H,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.83E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM393811
(US10597367, Example 99 | US9969726, Example 99)Show SMILES COc1ccc(cc1OC)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C26H18F4N2O4/c1-35-21-9-7-16(12-22(21)36-2)20-13-23(26(28,29)30)32-24(31-20)17-5-3-4-14(10-17)15-6-8-19(27)18(11-15)25(33)34/h3-13H,1-2H3,(H,33,34) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.48E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |