Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acyl-CoA desaturase 1
(Mus musculus) | BDBM50296525
(CHEMBL556495 | N-(5-(2,5-dichlorobenzyl)thiazol-2-...)Show SMILES COc1ccc(cc1OCCO)C(=O)Nc1ncc(Cc2cc(Cl)ccc2Cl)s1 Show InChI InChI=1S/C20H18Cl2N2O4S/c1-27-17-5-2-12(10-18(17)28-7-6-25)19(26)24-20-23-11-15(29-20)9-13-8-14(21)3-4-16(13)22/h2-5,8,10-11,25H,6-7,9H2,1H3,(H,23,24,26) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of SCD1 in mouse microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 mins |
Bioorg Med Chem Lett 19: 4151-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.119 BindingDB Entry DOI: 10.7270/Q21836H1 |
More data for this Ligand-Target Pair | |
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50296525
(CHEMBL556495 | N-(5-(2,5-dichlorobenzyl)thiazol-2-...)Show SMILES COc1ccc(cc1OCCO)C(=O)Nc1ncc(Cc2cc(Cl)ccc2Cl)s1 Show InChI InChI=1S/C20H18Cl2N2O4S/c1-27-17-5-2-12(10-18(17)28-7-6-25)19(26)24-20-23-11-15(29-20)9-13-8-14(21)3-4-16(13)22/h2-5,8,10-11,25H,6-7,9H2,1H3,(H,23,24,26) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 125 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of SCD1 in human microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 mins |
Bioorg Med Chem Lett 19: 4151-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.119 BindingDB Entry DOI: 10.7270/Q21836H1 |
More data for this Ligand-Target Pair | |
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50296525
(CHEMBL556495 | N-(5-(2,5-dichlorobenzyl)thiazol-2-...)Show SMILES COc1ccc(cc1OCCO)C(=O)Nc1ncc(Cc2cc(Cl)ccc2Cl)s1 Show InChI InChI=1S/C20H18Cl2N2O4S/c1-27-17-5-2-12(10-18(17)28-7-6-25)19(26)24-20-23-11-15(29-20)9-13-8-14(21)3-4-16(13)22/h2-5,8,10-11,25H,6-7,9H2,1H3,(H,23,24,26) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 429 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of human SCD1 expressed in HEK293A cells assessed as conversion of [14C]stearate to [14C]oleate |
Bioorg Med Chem Lett 19: 4151-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.119 BindingDB Entry DOI: 10.7270/Q21836H1 |
More data for this Ligand-Target Pair | |