Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50448676
(CHEMBL3127665)Show SMILES COc1ccc2CCN(C3CCN(CC3)c3ccc(nn3)-c3cnn(C)c3)c2c1 Show InChI InChI=1S/C22H26N6O/c1-26-15-17(14-23-26)20-5-6-22(25-24-20)27-10-8-18(9-11-27)28-12-7-16-3-4-19(29-2)13-21(16)28/h3-6,13-15,18H,7-12H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 317 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using stearoyl-[9,10-3H]-CoA as substrate |
Bioorg Med Chem Lett 24: 1437-41 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.075
BindingDB Entry DOI: 10.7270/Q26M38BM |
More data for this
Ligand-Target Pair | |
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50448676
(CHEMBL3127665)Show SMILES COc1ccc2CCN(C3CCN(CC3)c3ccc(nn3)-c3cnn(C)c3)c2c1 Show InChI InChI=1S/C22H26N6O/c1-26-15-17(14-23-26)20-5-6-22(25-24-20)27-10-8-18(9-11-27)28-12-7-16-3-4-19(29-2)13-21(16)28/h3-6,13-15,18H,7-12H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 407 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of SCD1 in human A431 cells assessed as [13C]-palmitic acid conversion to [13C]-palmitoleic acid after 4 hrs by LC/MS analysis |
Bioorg Med Chem Lett 24: 1437-41 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.075
BindingDB Entry DOI: 10.7270/Q26M38BM |
More data for this
Ligand-Target Pair | |