Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50261460
(CHEMBL4084404)Show SMILES COc1ccc2CN(CCc2c1)C(=O)C1CCN(CC1)c1c(cnc2ccc(F)cc12)C#N Show InChI InChI=1S/C26H25FN4O2/c1-33-22-4-2-19-16-31(11-8-18(19)12-22)26(32)17-6-9-30(10-7-17)25-20(14-28)15-29-24-5-3-21(27)13-23(24)25/h2-5,12-13,15,17H,6-11,16H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m... |
Bioorg Med Chem Lett 27: 4274-4279 (2017)
Article DOI: 10.1016/j.bmcl.2017.08.043
BindingDB Entry DOI: 10.7270/Q2KP84MJ |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50261460
(CHEMBL4084404)Show SMILES COc1ccc2CN(CCc2c1)C(=O)C1CCN(CC1)c1c(cnc2ccc(F)cc12)C#N Show InChI InChI=1S/C26H25FN4O2/c1-33-22-4-2-19-16-31(11-8-18(19)12-22)26(32)17-6-9-30(10-7-17)25-20(14-28)15-29-24-5-3-21(27)13-23(24)25/h2-5,12-13,15,17H,6-11,16H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 648 | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m... |
Bioorg Med Chem Lett 27: 4274-4279 (2017)
Article DOI: 10.1016/j.bmcl.2017.08.043
BindingDB Entry DOI: 10.7270/Q2KP84MJ |
More data for this
Ligand-Target Pair | |