Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50437063
(CHEMBL2403371)Show SMILES COc1ccc2NC(=O)\C(=C/c3[nH]c4CCN(Cc4c3Cl)C(C)=O)c2c1 Show InChI InChI=1S/C19H18ClN3O3/c1-10(24)23-6-5-16-14(9-23)18(20)17(21-16)8-13-12-7-11(26-2)3-4-15(12)22-19(13)25/h3-4,7-8,21H,5-6,9H2,1-2H3,(H,22,25)/b13-8- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of human LRRK2 (1885 to 2132) using 5-Fluo-Ahx-RLGRDKYKTLRQIRQGNTK-OH as substrate after 60 mins by fluorescence assay |
Bioorg Med Chem Lett 23: 4085-90 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.054
BindingDB Entry DOI: 10.7270/Q2SB474D |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50437063
(CHEMBL2403371)Show SMILES COc1ccc2NC(=O)\C(=C/c3[nH]c4CCN(Cc4c3Cl)C(C)=O)c2c1 Show InChI InChI=1S/C19H18ClN3O3/c1-10(24)23-6-5-16-14(9-23)18(20)17(21-16)8-13-12-7-11(26-2)3-4-15(12)22-19(13)25/h3-4,7-8,21H,5-6,9H2,1-2H3,(H,22,25)/b13-8- | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of RET (unknown origin) |
Bioorg Med Chem Lett 23: 4085-90 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.054
BindingDB Entry DOI: 10.7270/Q2SB474D |
More data for this
Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50437063
(CHEMBL2403371)Show SMILES COc1ccc2NC(=O)\C(=C/c3[nH]c4CCN(Cc4c3Cl)C(C)=O)c2c1 Show InChI InChI=1S/C19H18ClN3O3/c1-10(24)23-6-5-16-14(9-23)18(20)17(21-16)8-13-12-7-11(26-2)3-4-15(12)22-19(13)25/h3-4,7-8,21H,5-6,9H2,1-2H3,(H,22,25)/b13-8- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of ALK (unknown origin) |
Bioorg Med Chem Lett 23: 4085-90 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.054
BindingDB Entry DOI: 10.7270/Q2SB474D |
More data for this
Ligand-Target Pair | |