Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM132435
(US8841312, 182)Show SMILES COc1ccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c2n1 Show InChI InChI=1S/C24H28N8O/c1-33-21-9-7-18-19-15-27-24(30-23(19)32(22(18)29-21)16-4-2-3-5-16)28-20-8-6-17(14-26-20)31-12-10-25-11-13-31/h6-9,14-16,25H,2-5,10-13H2,1H3,(H,26,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM132435
(US8841312, 182)Show SMILES COc1ccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c2n1 Show InChI InChI=1S/C24H28N8O/c1-33-21-9-7-18-19-15-27-24(30-23(19)32(22(18)29-21)16-4-2-3-5-16)28-20-8-6-17(14-26-20)31-12-10-25-11-13-31/h6-9,14-16,25H,2-5,10-13H2,1H3,(H,26,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 113 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this Ligand-Target Pair | |