Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 378.3 BDBM50561333

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50561333 (CHEMBL4791435) Show SMILES COc1ccc2n(C)c3CCN(Cc3c2c1)C(=O)c1cc([nH]n1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of human CFTR F508 deletion mutant expressed in rat FRT cells coexpressing HS-YFP assessed as increase in iodide influx pre-incubated fo...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01050 BindingDB Entry DOI: 10.7270/Q2639TFP
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