Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 476.4 BDBM360587

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM360587 ((cis)-N-((5-(3-methoxyphenyl) isoquinolin-8-yl)met...) Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@@H]2c2ccc(cc2)C(F)(F)F)c2cnccc12 |r| Show InChI InChI=1S/C28H23F3N2O2/c1-35-21-4-2-3-18(13-21)22-10-7-19(26-16-32-12-11-23(22)26)15-33-27(34)25-14-24(25)17-5-8-20(9-6-17)28(29,30)31/h2-13,16,24-25H,14-15H2,1H3,(H,33,34)/t24-,25-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharpe & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9828369 (2017) BindingDB Entry DOI: 10.7270/Q2DN47C7
					More data for this Ligand-Target Pair