Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 414.4 BDBM360578

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM360578 (2-(3-fluorophenyl)-N-((5-(3- methoxyphenyl)isoquin...) Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)c2cccc(F)c2)c2cnccc12 Show InChI InChI=1S/C26H23FN2O2/c1-17(18-5-3-7-21(27)13-18)26(30)29-15-20-9-10-23(24-11-12-28-16-25(20)24)19-6-4-8-22(14-19)31-2/h3-14,16-17H,15H2,1-2H3,(H,29,30)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharpe & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9828369 (2017) BindingDB Entry DOI: 10.7270/Q2DN47C7
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