Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT) | BDBM50347808
(CHEMBL1802399)Show SMILES COc1cccc(c1)-c1cnc(N)nc1-c1c[nH]c2c(Br)cccc12 Show InChI InChI=1S/C19H15BrN4O/c1-25-12-5-2-4-11(8-12)14-9-23-19(21)24-17(14)15-10-22-18-13(15)6-3-7-16(18)20/h2-10,22H,1H3,(H2,21,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Clermont Universite£
Curated by ChEMBL
| Assay Description Inhibition of rat recombinant GST-tagged DYRK1A using myelin protein as substrate and [gamma32]-ATP after 30 mins by scintillation counting |
J Med Chem 54: 4474-89 (2011)
Article DOI: 10.1021/jm200464w BindingDB Entry DOI: 10.7270/Q2ZW1M8P |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Homo sapiens (Human)) | BDBM50347808
(CHEMBL1802399)Show SMILES COc1cccc(c1)-c1cnc(N)nc1-c1c[nH]c2c(Br)cccc12 Show InChI InChI=1S/C19H15BrN4O/c1-25-12-5-2-4-11(8-12)14-9-23-19(21)24-17(14)15-10-22-18-13(15)6-3-7-16(18)20/h2-10,22H,1H3,(H2,21,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
Clermont Universite£
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrate |
J Med Chem 54: 4474-89 (2011)
Article DOI: 10.1021/jm200464w BindingDB Entry DOI: 10.7270/Q2ZW1M8P |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM50347808
(CHEMBL1802399)Show SMILES COc1cccc(c1)-c1cnc(N)nc1-c1c[nH]c2c(Br)cccc12 Show InChI InChI=1S/C19H15BrN4O/c1-25-12-5-2-4-11(8-12)14-9-23-19(21)24-17(14)15-10-22-18-13(15)6-3-7-16(18)20/h2-10,22H,1H3,(H2,21,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Clermont Universite£
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK5/p25 using Histone H1 and [gamma32]-ATP after 30 mins by scintillation counting |
J Med Chem 54: 4474-89 (2011)
Article DOI: 10.1021/jm200464w BindingDB Entry DOI: 10.7270/Q2ZW1M8P |
More data for this Ligand-Target Pair | |