Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 395.2 BDBM50347810

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (RAT)	BDBM50347810 (CHEMBL1802396) Show SMILES COc1cccc(c1)-c1cnc(N)nc1-c1c[nH]c2cccc(Br)c12 Show InChI InChI=1S/C19H15BrN4O/c1-25-12-5-2-4-11(8-12)13-9-23-19(21)24-18(13)14-10-22-16-7-3-6-15(20)17(14)16/h2-10,22H,1H3,(H2,21,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Universite£ Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-tagged DYRK1A using myelin protein as substrate and [gamma32]-ATP after 30 mins by scintillation counting				J Med Chem 54: 4474-89 (2011) Article DOI: 10.1021/jm200464w BindingDB Entry DOI: 10.7270/Q2ZW1M8P
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1 (Homo sapiens (Human))	BDBM50347810 (CHEMBL1802396) Show SMILES COc1cccc(c1)-c1cnc(N)nc1-c1c[nH]c2cccc(Br)c12 Show InChI InChI=1S/C19H15BrN4O/c1-25-12-5-2-4-11(8-12)13-9-23-19(21)24-18(13)14-10-22-16-7-3-6-15(20)17(14)16/h2-10,22H,1H3,(H2,21,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Universite£ Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrate				J Med Chem 54: 4474-89 (2011) Article DOI: 10.1021/jm200464w BindingDB Entry DOI: 10.7270/Q2ZW1M8P
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50347810 (CHEMBL1802396) Show SMILES COc1cccc(c1)-c1cnc(N)nc1-c1c[nH]c2cccc(Br)c12 Show InChI InChI=1S/C19H15BrN4O/c1-25-12-5-2-4-11(8-12)13-9-23-19(21)24-18(13)14-10-22-16-7-3-6-15(20)17(14)16/h2-10,22H,1H3,(H2,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Universite£ Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK5/p25 using Histone H1 and [gamma32]-ATP after 30 mins by scintillation counting				J Med Chem 54: 4474-89 (2011) Article DOI: 10.1021/jm200464w BindingDB Entry DOI: 10.7270/Q2ZW1M8P
					More data for this Ligand-Target Pair