Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glycogen synthase kinase-3 alpha
(Homo sapiens (Human)) | BDBM303151
(US10137122, Compound 23)Show SMILES COc1cccc(c1)C1c2c(C)[nH]nc2NC2=C1C(=O)CC(C)(C)C2 |c:18| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| US Patent
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.; The General Hospital Corporation
US Patent
| Assay Description A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff... |
US Patent US10137122 (2018)
BindingDB Entry DOI: 10.7270/Q2DJ5HPX |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM303151
(US10137122, Compound 23)Show SMILES COc1cccc(c1)C1c2c(C)[nH]nc2NC2=C1C(=O)CC(C)(C)C2 |c:18| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| US Patent
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.; The General Hospital Corporation
US Patent
| Assay Description 20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ... |
US Patent US10137122 (2018)
BindingDB Entry DOI: 10.7270/Q2DJ5HPX |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM303151
(US10137122, Compound 23)Show SMILES COc1cccc(c1)C1c2c(C)[nH]nc2NC2=C1C(=O)CC(C)(C)C2 |c:18| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | 1.75E+4 | n/a | n/a | n/a | n/a | n/a |
The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.; The General Hospital Corporation
US Patent
| Assay Description Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr... |
US Patent US10137122 (2018)
BindingDB Entry DOI: 10.7270/Q2DJ5HPX |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM303151
(US10137122, Compound 23)Show SMILES COc1cccc(c1)C1c2c(C)[nH]nc2NC2=C1C(=O)CC(C)(C)C2 |c:18| | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a |
The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.; The General Hospital Corporation
US Patent
| |
US Patent US10137122 (2018)
BindingDB Entry DOI: 10.7270/Q2DJ5HPX |
More data for this Ligand-Target Pair | |