Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155747
(CHEMBL3781194)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C23H21N7O/c1-31-21-5-3-2-4-20(21)28-10-12-29(13-11-28)22-19-15-27-30(23(19)26-16-25-22)18-8-6-17(14-24)7-9-18/h2-9,15-16H,10-13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050 BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 3
(Homo sapiens (Human)) | BDBM50155747
(CHEMBL3781194)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C23H21N7O/c1-31-21-5-3-2-4-20(21)28-10-12-29(13-11-28)22-19-15-27-30(23(19)26-16-25-22)18-8-6-17(14-24)7-9-18/h2-9,15-16H,10-13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description Inhibition of human GLUT3 expressed in GLUT1 knock-out DLD1 cells assessed as ATP production co-incubated with 300 mM glucose for 16 hrs by CellTiter... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050 BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 2
(Homo sapiens (Human)) | BDBM50155747
(CHEMBL3781194)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C23H21N7O/c1-31-21-5-3-2-4-20(21)28-10-12-29(13-11-28)22-19-15-27-30(23(19)26-16-25-22)18-8-6-17(14-24)7-9-18/h2-9,15-16H,10-13H2,1H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description Inhibition of human GLUT2 expressed in CHO cells assessed as ATP production co-incubated with 30 mM fructose for 16 hrs by CellTiter-Glo assay in pre... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050 BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this Ligand-Target Pair | |