Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM380624
(6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)...)Show SMILES COc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2)c2cc(C)c3nnc(C)n3c2)c(OC)n1 Show InChI InChI=1S/C28H27ClN8O3/c1-14(2)36-23-21(31-25(36)20-12-30-28(40-6)32-26(20)39-5)27(38)37(22(23)17-7-9-18(29)10-8-17)19-11-15(3)24-34-33-16(4)35(24)13-19/h7-14,22H,1-6H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
Cancer Res 66: 8715-21 (2006)
BindingDB Entry DOI: 10.7270/Q2TM7DFQ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM380624
(6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)...)Show SMILES COc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2)c2cc(C)c3nnc(C)n3c2)c(OC)n1 Show InChI InChI=1S/C28H27ClN8O3/c1-14(2)36-23-21(31-25(36)20-12-30-28(40-6)32-26(20)39-5)27(38)37(22(23)17-7-9-18(29)10-8-17)19-11-15(3)24-34-33-16(4)35(24)13-19/h7-14,22H,1-6H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
Cancer Res 66: 8715-21 (2006)
BindingDB Entry DOI: 10.7270/Q2TM7DFQ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 2
(Homo sapiens (Human)) | BDBM380624
(6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)...)Show SMILES COc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2)c2cc(C)c3nnc(C)n3c2)c(OC)n1 Show InChI InChI=1S/C28H27ClN8O3/c1-14(2)36-23-21(31-25(36)20-12-30-28(40-6)32-26(20)39-5)27(38)37(22(23)17-7-9-18(29)10-8-17)19-11-15(3)24-34-33-16(4)35(24)13-19/h7-14,22H,1-6H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
Cancer Res 66: 8715-21 (2006)
BindingDB Entry DOI: 10.7270/Q2TM7DFQ |
More data for this
Ligand-Target Pair | |
CREB-binding protein
(Homo sapiens (Human)) | BDBM380624
(6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)...)Show SMILES COc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2)c2cc(C)c3nnc(C)n3c2)c(OC)n1 Show InChI InChI=1S/C28H27ClN8O3/c1-14(2)36-23-21(31-25(36)20-12-30-28(40-6)32-26(20)39-5)27(38)37(22(23)17-7-9-18(29)10-8-17)19-11-15(3)24-34-33-16(4)35(24)13-19/h7-14,22H,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ... |
Cancer Res 66: 8715-21 (2006)
BindingDB Entry DOI: 10.7270/Q2TM7DFQ |
More data for this
Ligand-Target Pair | |