Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-C chemokine receptor type 9
(Homo sapiens (Human)) | BDBM393585
(US9969687, Compound 261)Show SMILES COc1ncc(C)cc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl Show InChI InChI=1S/C25H24ClN3O5S/c1-14-12-19(22(34-5)27-13-14)29-23(30)20-17(26)10-11-18(21(20)24(29)31)28-35(32,33)16-8-6-15(7-9-16)25(2,3)4/h6-13,28H,1-5H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in... |
J Med Chem 52: 2652-5 (2009)
BindingDB Entry DOI: 10.7270/Q28W3GNH |
More data for this Ligand-Target Pair | |
C-C chemokine receptor type 9
(Homo sapiens (Human)) | BDBM393585
(US9969687, Compound 261)Show SMILES COc1ncc(C)cc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl Show InChI InChI=1S/C25H24ClN3O5S/c1-14-12-19(22(34-5)27-13-14)29-23(30)20-17(26)10-11-18(21(20)24(29)31)28-35(32,33)16-8-6-15(7-9-16)25(2,3)4/h6-13,28H,1-5H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Norgine Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubate... |
J Med Chem 59: 3098-111 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01840 BindingDB Entry DOI: 10.7270/Q28918WJ |
More data for this Ligand-Target Pair | |