Found 8 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM22351
(1,3-Diarylprop-2-yn-1-one, 13h | 1-(4-fluorophenyl...)Show InChI InChI=1S/C16H11FO3S/c1-21(19,20)15-9-2-12(3-10-15)4-11-16(18)13-5-7-14(17)8-6-13/h2-3,5-10H,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against ovine cyclooxygenase 2 |
Bioorg Med Chem Lett 15: 4842-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.036 BindingDB Entry DOI: 10.7270/Q2RJ4K7N |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM22351
(1,3-Diarylprop-2-yn-1-one, 13h | 1-(4-fluorophenyl...)Show InChI InChI=1S/C16H11FO3S/c1-21(19,20)15-9-2-12(3-10-15)4-11-16(18)13-5-7-14(17)8-6-13/h2-3,5-10H,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
| Assay Description The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as... |
J Med Chem 49: 1668-83 (2006)
Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S |
More data for this Ligand-Target Pair | |
Seed linoleate 13S-lipoxygenase-1
(Glycine max (soybean)) | BDBM22351
(1,3-Diarylprop-2-yn-1-one, 13h | 1-(4-fluorophenyl...)Show InChI InChI=1S/C16H11FO3S/c1-21(19,20)15-9-2-12(3-10-15)4-11-16(18)13-5-7-14(17)8-6-13/h2-3,5-10H,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
| Assay Description The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen... |
J Med Chem 49: 1668-83 (2006)
Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S |
More data for this Ligand-Target Pair | |
Seed linoleate 13S-lipoxygenase-1
(Glycine max (soybean)) | BDBM22351
(1,3-Diarylprop-2-yn-1-one, 13h | 1-(4-fluorophenyl...)Show InChI InChI=1S/C16H11FO3S/c1-21(19,20)15-9-2-12(3-10-15)4-11-16(18)13-5-7-14(17)8-6-13/h2-3,5-10H,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against 15-lipoxygenase obtained from soybean |
Bioorg Med Chem Lett 15: 4842-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.036 BindingDB Entry DOI: 10.7270/Q2RJ4K7N |
More data for this Ligand-Target Pair | |
Seed linoleate 13S-lipoxygenase-1
(Glycine max (soybean)) | BDBM22351
(1,3-Diarylprop-2-yn-1-one, 13h | 1-(4-fluorophenyl...)Show InChI InChI=1S/C16H11FO3S/c1-21(19,20)15-9-2-12(3-10-15)4-11-16(18)13-5-7-14(17)8-6-13/h2-3,5-10H,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against 5-lipoxygenase obtained from potato |
Bioorg Med Chem Lett 15: 4842-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.036 BindingDB Entry DOI: 10.7270/Q2RJ4K7N |
More data for this Ligand-Target Pair | |
Lipoxygenase
(Solanum tuberosum (potato)) | BDBM22351
(1,3-Diarylprop-2-yn-1-one, 13h | 1-(4-fluorophenyl...)Show InChI InChI=1S/C16H11FO3S/c1-21(19,20)15-9-2-12(3-10-15)4-11-16(18)13-5-7-14(17)8-6-13/h2-3,5-10H,1H3 | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
| Assay Description The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen... |
J Med Chem 49: 1668-83 (2006)
Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM22351
(1,3-Diarylprop-2-yn-1-one, 13h | 1-(4-fluorophenyl...)Show InChI InChI=1S/C16H11FO3S/c1-21(19,20)15-9-2-12(3-10-15)4-11-16(18)13-5-7-14(17)8-6-13/h2-3,5-10H,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Alberta
| Assay Description The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as... |
J Med Chem 49: 1668-83 (2006)
Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM22351
(1,3-Diarylprop-2-yn-1-one, 13h | 1-(4-fluorophenyl...)Show InChI InChI=1S/C16H11FO3S/c1-21(19,20)15-9-2-12(3-10-15)4-11-16(18)13-5-7-14(17)8-6-13/h2-3,5-10H,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against ovine cyclooxygenase 1 |
Bioorg Med Chem Lett 15: 4842-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.036 BindingDB Entry DOI: 10.7270/Q2RJ4K7N |
More data for this Ligand-Target Pair | |