Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Lipoxygenase
(Solanum tuberosum (potato)) | BDBM22366
(1,3-Diarylprop-2-yn-1-one, 26a | 3-(4-methanesulfo...)Show InChI InChI=1S/C13H9NO4S/c1-19(16,17)11-5-2-10(3-6-11)4-7-12(15)13-8-9-14-18-13/h2-3,5-6,8-9H,1H3 | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
| Assay Description The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen... |
J Med Chem 49: 1668-83 (2006)
Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S |
More data for this Ligand-Target Pair | |
Seed linoleate 13S-lipoxygenase-1
(Glycine max (soybean)) | BDBM22366
(1,3-Diarylprop-2-yn-1-one, 26a | 3-(4-methanesulfo...)Show InChI InChI=1S/C13H9NO4S/c1-19(16,17)11-5-2-10(3-6-11)4-7-12(15)13-8-9-14-18-13/h2-3,5-6,8-9H,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
| Assay Description The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen... |
J Med Chem 49: 1668-83 (2006)
Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM22366
(1,3-Diarylprop-2-yn-1-one, 26a | 3-(4-methanesulfo...)Show InChI InChI=1S/C13H9NO4S/c1-19(16,17)11-5-2-10(3-6-11)4-7-12(15)13-8-9-14-18-13/h2-3,5-6,8-9H,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
| Assay Description The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as... |
J Med Chem 49: 1668-83 (2006)
Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM22366
(1,3-Diarylprop-2-yn-1-one, 26a | 3-(4-methanesulfo...)Show InChI InChI=1S/C13H9NO4S/c1-19(16,17)11-5-2-10(3-6-11)4-7-12(15)13-8-9-14-18-13/h2-3,5-6,8-9H,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.22E+4 | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Alberta
| Assay Description The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as... |
J Med Chem 49: 1668-83 (2006)
Article DOI: 10.1021/jm0510474 BindingDB Entry DOI: 10.7270/Q2DV1H5S |
More data for this Ligand-Target Pair | |