Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Programmed cell death 1 ligand 1
(Homo sapiens (Human)) | BDBM412155
(US10392405, Compound Id 1.019 | US11059834, Compou...)Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1cccc(OCCCN2CCC(O)CC2)c1C |r| Show InChI InChI=1S/C45H55ClN4O7/c1-30-33(10-7-11-37(30)38-12-8-14-41(31(38)2)55-21-9-18-50-19-15-36(51)16-20-50)29-57-43-24-42-34(23-39(43)46)27-49-40(45(53)54)13-5-3-4-6-17-48-44(52)35-22-32(28-56-42)25-47-26-35/h7-8,10-12,14,22-26,36,40,49,51H,3-6,9,13,15-21,27-29H2,1-2H3,(H,48,52)(H,53,54)/t40-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| UniChem
| | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2TB1C1W |
More data for this
Ligand-Target Pair | |
Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E]
(Homo sapiens (Human)) | BDBM412155
(US10392405, Compound Id 1.019 | US11059834, Compou...)Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1cccc(OCCCN2CCC(O)CC2)c1C |r| Show InChI InChI=1S/C45H55ClN4O7/c1-30-33(10-7-11-37(30)38-12-8-14-41(31(38)2)55-21-9-18-50-19-15-36(51)16-20-50)29-57-43-24-42-34(23-39(43)46)27-49-40(45(53)54)13-5-3-4-6-17-48-44(52)35-22-32(28-56-42)25-47-26-35/h7-8,10-12,14,22-26,36,40,49,51H,3-6,9,13,15-21,27-29H2,1-2H3,(H,48,52)(H,53,54)/t40-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2F192VF |
More data for this
Ligand-Target Pair | |
Programmed cell death 1 ligand 1
(Homo sapiens (Human)) | BDBM412155
(US10392405, Compound Id 1.019 | US11059834, Compou...)Show SMILES Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCCCC[C@H](NCc3cc2Cl)C(O)=O)cccc1-c1cccc(OCCCN2CCC(O)CC2)c1C |r| Show InChI InChI=1S/C45H55ClN4O7/c1-30-33(10-7-11-37(30)38-12-8-14-41(31(38)2)55-21-9-18-50-19-15-36(51)16-20-50)29-57-43-24-42-34(23-39(43)46)27-49-40(45(53)54)13-5-3-4-6-17-48-44(52)35-22-32(28-56-42)25-47-26-35/h7-8,10-12,14,22-26,36,40,49,51H,3-6,9,13,15-21,27-29H2,1-2H3,(H,48,52)(H,53,54)/t40-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemoCentryx, Inc.
US Patent
| Assay Description
96 Well plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in ... |
US Patent US10392405 (2019)
BindingDB Entry DOI: 10.7270/Q2057J9N |
More data for this
Ligand-Target Pair | |