Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM338132
(US9751854, Compound I-308 | US9802960, Compound I-...)Show SMILES Cc1c(NS(=O)(=O)c2ccc(F)cc2F)c(Cl)ncc1-c1ccnc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C21H17ClF2N4O3S/c1-11-15(13-6-7-25-18(8-13)27-21(29)12-2-3-12)10-26-20(22)19(11)28-32(30,31)17-5-4-14(23)9-16(17)24/h4-10,12,28H,2-3H2,1H3,(H,25,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
US Patent
| Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro... |
US Patent US9802960 (2017)
BindingDB Entry DOI: 10.7270/Q2D79DJ9 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM338132
(US9751854, Compound I-308 | US9802960, Compound I-...)Show SMILES Cc1c(NS(=O)(=O)c2ccc(F)cc2F)c(Cl)ncc1-c1ccnc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C21H17ClF2N4O3S/c1-11-15(13-6-7-25-18(8-13)27-21(29)12-2-3-12)10-26-20(22)19(11)28-32(30,31)17-5-4-14(23)9-16(17)24/h4-10,12,28H,2-3H2,1H3,(H,25,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
US Patent
| Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro... |
US Patent US9751854 (2017)
BindingDB Entry DOI: 10.7270/Q2KS6TNJ |
More data for this
Ligand-Target Pair | |