Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM50017271
(CHEMBL3287726 | US10099993, Compound 75)Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(F)c(c1)C(O)=O)C(=O)CC(C)(C)C Show InChI InChI=1S/C24H29FO6/c1-15-21(10-8-17(22(15)27)20(26)14-24(2,3)4)31-12-6-5-11-30-16-7-9-19(25)18(13-16)23(28)29/h7-10,13,27H,5-6,11-12,14H2,1-4H3,(H,28,29) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 258 | n/a | n/a | n/a | n/a |
Sanford-Burnham Medical Research Institute
Curated by ChEMBL
| Assay Description Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated... |
J Med Chem 57: 4154-72 (2014)
Article DOI: 10.1021/jm5000563 BindingDB Entry DOI: 10.7270/Q2GH9KH9 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Homo sapiens (Human)) | BDBM50017271
(CHEMBL3287726 | US10099993, Compound 75)Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(F)c(c1)C(O)=O)C(=O)CC(C)(C)C Show InChI InChI=1S/C24H29FO6/c1-15-21(10-8-17(22(15)27)20(26)14-24(2,3)4)31-12-6-5-11-30-16-7-9-19(25)18(13-16)23(28)29/h7-10,13,27H,5-6,11-12,14H2,1-4H3,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | n/a | n/a | 258 | n/a | n/a | n/a | n/a |
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
US Patent
| |
US Patent US10099993 (2018)
BindingDB Entry DOI: 10.7270/Q2Z89FFP |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50017271
(CHEMBL3287726 | US10099993, Compound 75)Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(F)c(c1)C(O)=O)C(=O)CC(C)(C)C Show InChI InChI=1S/C24H29FO6/c1-15-21(10-8-17(22(15)27)20(26)14-24(2,3)4)31-12-6-5-11-30-16-7-9-19(25)18(13-16)23(28)29/h7-10,13,27H,5-6,11-12,14H2,1-4H3,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | n/a | n/a | 208 | n/a | n/a | 7.3 | 25 |
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
US Patent
| Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10099993 (2018)
BindingDB Entry DOI: 10.7270/Q2Z89FFP |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50017271
(CHEMBL3287726 | US10099993, Compound 75)Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(F)c(c1)C(O)=O)C(=O)CC(C)(C)C Show InChI InChI=1S/C24H29FO6/c1-15-21(10-8-17(22(15)27)20(26)14-24(2,3)4)31-12-6-5-11-30-16-7-9-19(25)18(13-16)23(28)29/h7-10,13,27H,5-6,11-12,14H2,1-4H3,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 208 | n/a | n/a | n/a | n/a |
Sanford-Burnham Medical Research Institute
Curated by ChEMBL
| Assay Description Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated... |
J Med Chem 57: 4154-72 (2014)
Article DOI: 10.1021/jm5000563 BindingDB Entry DOI: 10.7270/Q2GH9KH9 |
More data for this Ligand-Target Pair | |