Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Programmed cell death 1 ligand 1
(Homo sapiens (Human)) | BDBM482528
(US10919852, Compound TABLE 1.227 | US11708326, Com...)Show SMILES Cc1c(OCCCN2CCC(F)CC2)cccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cc(cc(c2)C#N)C#N)c(CN[C@H]2CCC(=O)NC2)cc1Cl |r| Show InChI InChI=1S/C45H47ClFN5O4/c1-29-36(5-3-8-41(29)54-18-4-15-52-16-13-34(47)14-17-52)37-6-2-7-39-38(37)10-11-42(39)56-44-23-43(55-28-32-20-30(24-48)19-31(21-32)25-49)33(22-40(44)46)26-50-35-9-12-45(53)51-27-35/h2-3,5-8,19-23,34-35,42,50H,4,9-18,26-28H2,1H3,(H,51,53)/t35-,42-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| | n/a | n/a | 253 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q22N56DJ |
More data for this
Ligand-Target Pair | |
Programmed cell death protein 1
(Homo sapiens) | BDBM482528
(US10919852, Compound TABLE 1.227 | US11708326, Com...)Show SMILES Cc1c(OCCCN2CCC(F)CC2)cccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cc(cc(c2)C#N)C#N)c(CN[C@H]2CCC(=O)NC2)cc1Cl |r| Show InChI InChI=1S/C45H47ClFN5O4/c1-29-36(5-3-8-41(29)54-18-4-15-52-16-13-34(47)14-17-52)37-6-2-7-39-38(37)10-11-42(39)56-44-23-43(55-28-32-20-30(24-48)19-31(21-32)25-49)33(22-40(44)46)26-50-35-9-12-45(53)51-27-35/h2-3,5-8,19-23,34-35,42,50H,4,9-18,26-28H2,1H3,(H,51,53)/t35-,42-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 253 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemoCentryx, Inc.
US Patent
| Assay Description
96 Well plates were coated with 1 g/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in PBS (W... |
US Patent US10919852 (2021)
BindingDB Entry DOI: 10.7270/Q2RF5Z3R |
More data for this
Ligand-Target Pair | |