Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 468.4 BDBM50346274

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat))	BDBM50346274 (CHEMBL1782548 | sodium(3R,5R)-7-(4-(benzylcarbamoy...) Show SMILES Cc1c(nc(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C25H28FN3O5/c1-16-23(25(34)27-15-17-5-3-2-4-6-17)28-24(18-7-9-19(26)10-8-18)29(16)12-11-20(30)13-21(31)14-22(32)33/h2-10,20-21,30-31H,11-15H2,1H3,(H,27,34)(H,32,33)/p-1/t20-,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrat...				Bioorg Med Chem Lett 21: 2725-31 (2011) Article DOI: 10.1016/j.bmcl.2010.11.103 BindingDB Entry DOI: 10.7270/Q2H995J1
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