Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 390.4 BDBM50327791

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50327791 ((R)-2-amino-2-(2,3-dihydro-1H-inden-2-yl)-1-(4-(5-...) Show SMILES Cc1c[nH]c2ncnc(N3CCN(CC3)C(=O)[C@H](N)C3Cc4ccccc4C3)c12 |r| Show InChI InChI=1S/C22H26N6O/c1-14-12-24-20-18(14)21(26-13-25-20)27-6-8-28(9-7-27)22(29)19(23)17-10-15-4-2-3-5-16(15)11-17/h2-5,12-13,17,19H,6-11,23H2,1H3,(H,24,25,26)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc Curated by ChEMBL					Assay Description Inhibition of AKT1 by IMAP assay				Bioorg Med Chem Lett 20: 5607-12 (2010) Article DOI: 10.1016/j.bmcl.2010.08.053 BindingDB Entry DOI: 10.7270/Q2M908XQ
					More data for this Ligand-Target Pair
Proline-rich AKT1 substrate 1 (Homo sapiens (Human))	BDBM50327791 ((R)-2-amino-2-(2,3-dihydro-1H-inden-2-yl)-1-(4-(5-...) Show SMILES Cc1c[nH]c2ncnc(N3CCN(CC3)C(=O)[C@H](N)C3Cc4ccccc4C3)c12 |r| Show InChI InChI=1S/C22H26N6O/c1-14-12-24-20-18(14)21(26-13-25-20)27-6-8-28(9-7-27)22(29)19(23)17-10-15-4-2-3-5-16(15)11-17/h2-5,12-13,17,19H,6-11,23H2,1H3,(H,24,25,26)/t19-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc Curated by ChEMBL					Assay Description Inhibition of PRAS40 phosphorylation at Thr246 in human LNCaP cells after 1.5 hrs				Bioorg Med Chem Lett 20: 5607-12 (2010) Article DOI: 10.1016/j.bmcl.2010.08.053 BindingDB Entry DOI: 10.7270/Q2M908XQ
					More data for this Ligand-Target Pair