Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50327790
((R)-2-amino-3-(4-fluorophenyl)-1-(4-(5-methyl-7H-p...)Show SMILES Cc1c[nH]c2ncnc(N3CCN(CC3)C(=O)[C@H](N)Cc3ccc(F)cc3)c12 |r| Show InChI InChI=1S/C20H23FN6O/c1-13-11-23-18-17(13)19(25-12-24-18)26-6-8-27(9-7-26)20(28)16(22)10-14-2-4-15(21)5-3-14/h2-5,11-12,16H,6-10,22H2,1H3,(H,23,24,25)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
Curated by ChEMBL
| Assay Description Inhibition of Akt1 |
Bioorg Med Chem Lett 20: 7037-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.112 BindingDB Entry DOI: 10.7270/Q2TM7BBJ |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50327790
((R)-2-amino-3-(4-fluorophenyl)-1-(4-(5-methyl-7H-p...)Show SMILES Cc1c[nH]c2ncnc(N3CCN(CC3)C(=O)[C@H](N)Cc3ccc(F)cc3)c12 |r| Show InChI InChI=1S/C20H23FN6O/c1-13-11-23-18-17(13)19(25-12-24-18)26-6-8-27(9-7-26)20(28)16(22)10-14-2-4-15(21)5-3-14/h2-5,11-12,16H,6-10,22H2,1H3,(H,23,24,25)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description Inhibition of AKT1 by IMAP assay |
Bioorg Med Chem Lett 20: 5607-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.053 BindingDB Entry DOI: 10.7270/Q2M908XQ |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50327790
((R)-2-amino-3-(4-fluorophenyl)-1-(4-(5-methyl-7H-p...)Show SMILES Cc1c[nH]c2ncnc(N3CCN(CC3)C(=O)[C@H](N)Cc3ccc(F)cc3)c12 |r| Show InChI InChI=1S/C20H23FN6O/c1-13-11-23-18-17(13)19(25-12-24-18)26-6-8-27(9-7-26)20(28)16(22)10-14-2-4-15(21)5-3-14/h2-5,11-12,16H,6-10,22H2,1H3,(H,23,24,25)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
Curated by ChEMBL
| Assay Description Inhibition of Akt in human LNCaP cell assessed as inhibition of PRAS40 phosphorylation |
Bioorg Med Chem Lett 20: 7037-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.112 BindingDB Entry DOI: 10.7270/Q2TM7BBJ |
More data for this Ligand-Target Pair | |
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM50327790
((R)-2-amino-3-(4-fluorophenyl)-1-(4-(5-methyl-7H-p...)Show SMILES Cc1c[nH]c2ncnc(N3CCN(CC3)C(=O)[C@H](N)Cc3ccc(F)cc3)c12 |r| Show InChI InChI=1S/C20H23FN6O/c1-13-11-23-18-17(13)19(25-12-24-18)26-6-8-27(9-7-26)20(28)16(22)10-14-2-4-15(21)5-3-14/h2-5,11-12,16H,6-10,22H2,1H3,(H,23,24,25)/t16-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description Inhibition of PRAS40 phosphorylation at Thr246 in human LNCaP cells after 1.5 hrs |
Bioorg Med Chem Lett 20: 5607-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.053 BindingDB Entry DOI: 10.7270/Q2M908XQ |
More data for this Ligand-Target Pair | |