Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM271371
(US10064861, Compound 26)Show SMILES Cc1cc(=O)n2Cc3cccc(c3)C(=O)Nc3nc4ccccc4n3CCn3cc(cn3)-c1n2 Show InChI InChI=1S/C25H21N7O2/c1-16-11-22(33)32-14-17-5-4-6-18(12-17)24(34)28-25-27-20-7-2-3-8-21(20)31(25)10-9-30-15-19(13-26-30)23(16)29-32/h2-8,11-13,15H,9-10,14H2,1H3,(H,27,28,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Merck Patent GmbH
US Patent
| Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ... |
US Patent US10064861 (2018)
BindingDB Entry DOI: 10.7270/Q2NV9M8K |
More data for this
Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 1
(Homo sapiens (Human)) | BDBM271371
(US10064861, Compound 26)Show SMILES Cc1cc(=O)n2Cc3cccc(c3)C(=O)Nc3nc4ccccc4n3CCn3cc(cn3)-c1n2 Show InChI InChI=1S/C25H21N7O2/c1-16-11-22(33)32-14-17-5-4-6-18(12-17)24(34)28-25-27-20-7-2-3-8-21(20)31(25)10-9-30-15-19(13-26-30)23(16)29-32/h2-8,11-13,15H,9-10,14H2,1H3,(H,27,28,34) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Merck Patent GmbH
US Patent
| Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA... |
US Patent US10064861 (2018)
BindingDB Entry DOI: 10.7270/Q2NV9M8K |
More data for this
Ligand-Target Pair | |