Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM372323
(N-[1-(2,5-dichloro-4- pyridyl)azetidin-3-yl]- 7,9-...)Show SMILES Cc1cc(C)c2c(n1)oc1c(NC3CN(C3)c3cc(Cl)ncc3Cl)ncnc21 Show InChI InChI=1S/C19H16Cl2N6O/c1-9-3-10(2)25-19-15(9)16-17(28-19)18(24-8-23-16)26-11-6-27(7-11)13-4-14(21)22-5-12(13)20/h3-5,8,11H,6-7H2,1-2H3,(H,23,24,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.49E+3 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Positive allosteric modulation of human muscarinic acetylcholine M4/Gqi5 receptor expressed in CHO cells in presence of acetylcholine at EC20 concent... |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128416
BindingDB Entry DOI: 10.7270/Q22R3WHF |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM372323
(N-[1-(2,5-dichloro-4- pyridyl)azetidin-3-yl]- 7,9-...)Show SMILES Cc1cc(C)c2c(n1)oc1c(NC3CN(C3)c3cc(Cl)ncc3Cl)ncnc21 Show InChI InChI=1S/C19H16Cl2N6O/c1-9-3-10(2)25-19-15(9)16-17(28-19)18(24-8-23-16)26-11-6-27(7-11)13-4-14(21)22-5-12(13)20/h3-5,8,11H,6-7H2,1-2H3,(H,23,24,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.49E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
| Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated... |
J Med Chem 48: 6169-73 (2005)
BindingDB Entry DOI: 10.7270/Q2W09880 |
More data for this
Ligand-Target Pair | |