Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 601.1 BDBM104818

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysosomal Pro-X carboxypeptidase (Homo sapiens (Human))	BDBM104818 (US8569299, 7) Show SMILES Cc1cc(C2CCN(CC2)C(=O)[C@@H]2C[C@](C)(C[C@H]2c2ccc(F)cc2F)N2CCOCC2)n(n1)-c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C32H36ClF3N4O2/c1-20-15-30(40(37-20)23-4-6-28(35)27(33)17-23)21-7-9-38(10-8-21)31(41)26-19-32(2,39-11-13-42-14-12-39)18-25(26)24-5-3-22(34)16-29(24)36/h3-6,15-17,21,25-26H,7-14,18-19H2,1-2H3/t25-,26+,32-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.30	n/a	n/a	n/a	n/a	5.5	37
Merck Sharp & Dohme Corp US Patent					Assay Description The potency of compounds against PRCP was determined by a fluorescence intensity kinetic assay measuring the IC50 values of PRCP inhibitor test compo...				US Patent US8569299 (2013) BindingDB Entry DOI: 10.7270/Q2K9365V
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