Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM249579
(US9447038, 7)Show SMILES Cc1cc(CN(C(CC(O)=O)c2ccc(Cl)cc2)C2CCC2)ccc1OCCn1c(=O)ccn(C)c1=O Show InChI InChI=1S/C28H32ClN3O5/c1-19-16-20(6-11-25(19)37-15-14-31-26(33)12-13-30(2)28(31)36)18-32(23-4-3-5-23)24(17-27(34)35)21-7-9-22(29)10-8-21/h6-13,16,23-24H,3-5,14-15,17-18H2,1-2H3,(H,34,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Co. Ltd
Curated by ChEMBL
| Assay Description Displacement of [125I]-CXCL10 from human recombinant CXCR3 transfected in Flp-In-CHO cell membranes after 60 mins by gamma counting method |
Bioorg Med Chem Lett 26: 5429-5437 (2016)
Article DOI: 10.1016/j.bmcl.2016.10.038 BindingDB Entry DOI: 10.7270/Q2514164 |
More data for this Ligand-Target Pair | |
C-X-C motif chemokine 10
(Homo sapiens (Human)) | BDBM249579
(US9447038, 7)Show SMILES Cc1cc(CN(C(CC(O)=O)c2ccc(Cl)cc2)C2CCC2)ccc1OCCn1c(=O)ccn(C)c1=O Show InChI InChI=1S/C28H32ClN3O5/c1-19-16-20(6-11-25(19)37-15-14-31-26(33)12-13-30(2)28(31)36)18-32(23-4-3-5-23)24(17-27(34)35)21-7-9-22(29)10-8-21/h6-13,16,23-24H,3-5,14-15,17-18H2,1-2H3,(H,34,35) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi
US Patent
| Assay Description The composition of the binding assay buffer is determined in a course of detailed optimization procedure. This resulted in a binding assay buffer con... |
US Patent US9447038 (2016)
BindingDB Entry DOI: 10.7270/Q29G5KQK |
More data for this Ligand-Target Pair | |