Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50443350
(CHEMBL3086038 | US8669252, 35)Show SMILES Cc1cc(ccn1)C(NC(=O)[C@@H]1CC[C@H](C[C@H]1c1ccc(Br)cc1)N1CCOCC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H33BrClN3O2/c1-20-18-23(12-13-33-20)29(22-4-8-25(32)9-5-22)34-30(36)27-11-10-26(35-14-16-37-17-15-35)19-28(27)21-2-6-24(31)7-3-21/h2-9,12-13,18,26-29H,10-11,14-17,19H2,1H3,(H,34,36)/t26-,27-,28+,29?/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by fluorescence assay |
Bioorg Med Chem Lett 23: 6228-33 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.094
BindingDB Entry DOI: 10.7270/Q2DZ09Q4 |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50443350
(CHEMBL3086038 | US8669252, 35)Show SMILES Cc1cc(ccn1)C(NC(=O)[C@@H]1CC[C@H](C[C@H]1c1ccc(Br)cc1)N1CCOCC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H33BrClN3O2/c1-20-18-23(12-13-33-20)29(22-4-8-25(32)9-5-22)34-30(36)27-11-10-26(35-14-16-37-17-15-35)19-28(27)21-2-6-24(31)7-3-21/h2-9,12-13,18,26-29H,10-11,14-17,19H2,1H3,(H,34,36)/t26-,27-,28+,29?/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
The potency of compounds of formula I against PrCP was determined by a fluorescence intensity kinetic assay measuring the IC50 values of PrCP inhibit... |
US Patent US8669252 (2014)
BindingDB Entry DOI: 10.7270/Q2J9652X |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Mus musculus) | BDBM50443350
(CHEMBL3086038 | US8669252, 35)Show SMILES Cc1cc(ccn1)C(NC(=O)[C@@H]1CC[C@H](C[C@H]1c1ccc(Br)cc1)N1CCOCC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H33BrClN3O2/c1-20-18-23(12-13-33-20)29(22-4-8-25(32)9-5-22)34-30(36)27-11-10-26(35-14-16-37-17-15-35)19-28(27)21-2-6-24(31)7-3-21/h2-9,12-13,18,26-29H,10-11,14-17,19H2,1H3,(H,34,36)/t26-,27-,28+,29?/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by fluorescence assay |
Bioorg Med Chem Lett 23: 6228-33 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.094
BindingDB Entry DOI: 10.7270/Q2DZ09Q4 |
More data for this
Ligand-Target Pair | |