Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 1
(Homo sapiens (Human)) | BDBM477913
(6-((3-((1R,5S,6S)-3-amino-5-(fluoromethyl)-1-((E)-...)Show SMILES Cc1cc(cnc1C#Cc1ccc(F)c(c1)[C@@]1(CF)N=C(N)S[C@]2(C[C@@H]12)\C=C\C(=O)N1CCOCC1)C#N |r,t:21| Show InChI InChI=1S/C28H25F2N5O2S/c1-18-12-20(15-31)16-33-23(18)5-3-19-2-4-22(30)21(13-19)28(17-29)24-14-27(24,38-26(32)34-28)7-6-25(36)35-8-10-37-11-9-35/h2,4,6-7,12-13,16,24H,8-11,14,17H2,1H3,(H2,32,34)/b7-6+/t24-,27+,28-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ... |
US Patent US10889581 (2021)
BindingDB Entry DOI: 10.7270/Q20868DB |
More data for this
Ligand-Target Pair | |
Beta-secretase 2
(Homo sapiens (Human)) | BDBM477913
(6-((3-((1R,5S,6S)-3-amino-5-(fluoromethyl)-1-((E)-...)Show SMILES Cc1cc(cnc1C#Cc1ccc(F)c(c1)[C@@]1(CF)N=C(N)S[C@]2(C[C@@H]12)\C=C\C(=O)N1CCOCC1)C#N |r,t:21| Show InChI InChI=1S/C28H25F2N5O2S/c1-18-12-20(15-31)16-33-23(18)5-3-19-2-4-22(30)21(13-19)28(17-29)24-14-27(24,38-26(32)34-28)7-6-25(36)35-8-10-37-11-9-35/h2,4,6-7,12-13,16,24H,8-11,14,17H2,1H3,(H2,32,34)/b7-6+/t24-,27+,28-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 166 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ... |
US Patent US10889581 (2021)
BindingDB Entry DOI: 10.7270/Q20868DB |
More data for this
Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM477913
(6-((3-((1R,5S,6S)-3-amino-5-(fluoromethyl)-1-((E)-...)Show SMILES Cc1cc(cnc1C#Cc1ccc(F)c(c1)[C@@]1(CF)N=C(N)S[C@]2(C[C@@H]12)\C=C\C(=O)N1CCOCC1)C#N |r,t:21| Show InChI InChI=1S/C28H25F2N5O2S/c1-18-12-20(15-31)16-33-23(18)5-3-19-2-4-22(30)21(13-19)28(17-29)24-14-27(24,38-26(32)34-28)7-6-25(36)35-8-10-37-11-9-35/h2,4,6-7,12-13,16,24H,8-11,14,17H2,1H3,(H2,32,34)/b7-6+/t24-,27+,28-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.72E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ... |
US Patent US10889581 (2021)
BindingDB Entry DOI: 10.7270/Q20868DB |
More data for this
Ligand-Target Pair | |