Found 6 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM295094
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1COC1 Show InChI InChI=1S/C20H22N4O4S/c1-12-3-4-16(29(25,26)23-8-14-10-27-11-14)7-17(12)15-6-18(20(21)22-9-15)19-5-13(2)24-28-19/h3-7,9,14,23H,8,10-11H2,1-2H3,(H2,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG
US Patent
| Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha
(Homo sapiens (Human)) | BDBM295094
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1COC1 Show InChI InChI=1S/C20H22N4O4S/c1-12-3-4-16(29(25,26)23-8-14-10-27-11-14)7-17(12)15-6-18(20(21)22-9-15)19-5-13(2)24-28-19/h3-7,9,14,23H,8,10-11H2,1-2H3,(H2,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM295094
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1COC1 Show InChI InChI=1S/C20H22N4O4S/c1-12-3-4-16(29(25,26)23-8-14-10-27-11-14)7-17(12)15-6-18(20(21)22-9-15)19-5-13(2)24-28-19/h3-7,9,14,23H,8,10-11H2,1-2H3,(H2,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG
US Patent
| Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4-kinase beta
(Homo sapiens (Human)) | BDBM295094
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1COC1 Show InChI InChI=1S/C20H22N4O4S/c1-12-3-4-16(29(25,26)23-8-14-10-27-11-14)7-17(12)15-6-18(20(21)22-9-15)19-5-13(2)24-28-19/h3-7,9,14,23H,8,10-11H2,1-2H3,(H2,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM295094
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1COC1 Show InChI InChI=1S/C20H22N4O4S/c1-12-3-4-16(29(25,26)23-8-14-10-27-11-14)7-17(12)15-6-18(20(21)22-9-15)19-5-13(2)24-28-19/h3-7,9,14,23H,8,10-11H2,1-2H3,(H2,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM295094
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1COC1 Show InChI InChI=1S/C20H22N4O4S/c1-12-3-4-16(29(25,26)23-8-14-10-27-11-14)7-17(12)15-6-18(20(21)22-9-15)19-5-13(2)24-28-19/h3-7,9,14,23H,8,10-11H2,1-2H3,(H2,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10112926 (2018)
BindingDB Entry DOI: 10.7270/Q22R3TQ9 |
More data for this
Ligand-Target Pair | |