Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393877
(US10597367, Example 173B | US9969726, Example 173B)Show SMILES Cc1cc2NC(CC(=O)Nc2cc1C(F)(F)F)c1cccc(Oc2cccc(Br)c2)c1 |w:5.18| Show InChI InChI=1S/C23H18BrF3N2O2/c1-13-8-20-21(11-18(13)23(25,26)27)29-22(30)12-19(28-20)14-4-2-6-16(9-14)31-17-7-3-5-15(24)10-17/h2-11,19,28H,12H2,1H3,(H,29,30) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM393877
(US10597367, Example 173B | US9969726, Example 173B)Show SMILES Cc1cc2NC(CC(=O)Nc2cc1C(F)(F)F)c1cccc(Oc2cccc(Br)c2)c1 |w:5.18| Show InChI InChI=1S/C23H18BrF3N2O2/c1-13-8-20-21(11-18(13)23(25,26)27)29-22(30)12-19(28-20)14-4-2-6-16(9-14)31-17-7-3-5-15(24)10-17/h2-11,19,28H,12H2,1H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.25E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393877
(US10597367, Example 173B | US9969726, Example 173B)Show SMILES Cc1cc2NC(CC(=O)Nc2cc1C(F)(F)F)c1cccc(Oc2cccc(Br)c2)c1 |w:5.18| Show InChI InChI=1S/C23H18BrF3N2O2/c1-13-8-20-21(11-18(13)23(25,26)27)29-22(30)12-19(28-20)14-4-2-6-16(9-14)31-17-7-3-5-15(24)10-17/h2-11,19,28H,12H2,1H3,(H,29,30) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM393877
(US10597367, Example 173B | US9969726, Example 173B)Show SMILES Cc1cc2NC(CC(=O)Nc2cc1C(F)(F)F)c1cccc(Oc2cccc(Br)c2)c1 |w:5.18| Show InChI InChI=1S/C23H18BrF3N2O2/c1-13-8-20-21(11-18(13)23(25,26)27)29-22(30)12-19(28-20)14-4-2-6-16(9-14)31-17-7-3-5-15(24)10-17/h2-11,19,28H,12H2,1H3,(H,29,30) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.25E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |