Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E synthase
(Homo sapiens (Human)) | BDBM50452045
(CHEMBL4211033)Show SMILES Cc1cc2c3[nH]c(Nc4c(Cl)cccc4Cl)nc3cc(C(=O)Nc3cccc(c3)C(F)(F)F)c2o1 Show InChI InChI=1S/C24H15Cl2F3N4O2/c1-11-8-14-19-18(31-23(32-19)33-20-16(25)6-3-7-17(20)26)10-15(21(14)35-11)22(34)30-13-5-2-4-12(9-13)24(27,28)29/h2-10H,1H3,(H,30,34)(H2,31,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human mPGES1 expressed in CHO cells using PGH2 as substrate pretreated for 10 mins followed by substrate addition measured ... |
Bioorg Med Chem Lett 27: 5131-5138 (2017)
Article DOI: 10.1016/j.bmcl.2017.10.062
BindingDB Entry DOI: 10.7270/Q2JS9T0V |
More data for this
Ligand-Target Pair | |
Prostaglandin E synthase
(Homo sapiens (Human)) | BDBM50452045
(CHEMBL4211033)Show SMILES Cc1cc2c3[nH]c(Nc4c(Cl)cccc4Cl)nc3cc(C(=O)Nc3cccc(c3)C(F)(F)F)c2o1 Show InChI InChI=1S/C24H15Cl2F3N4O2/c1-11-8-14-19-18(31-23(32-19)33-20-16(25)6-3-7-17(20)26)10-15(21(14)35-11)22(34)30-13-5-2-4-12(9-13)24(27,28)29/h2-10H,1H3,(H,30,34)(H2,31,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description
Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta induced PGE2 production pretreated for 30 mins followed by IL-1beta additi... |
Bioorg Med Chem Lett 27: 5131-5138 (2017)
Article DOI: 10.1016/j.bmcl.2017.10.062
BindingDB Entry DOI: 10.7270/Q2JS9T0V |
More data for this
Ligand-Target Pair | |
Prostaglandin E synthase
(Homo sapiens (Human)) | BDBM50452045
(CHEMBL4211033)Show SMILES Cc1cc2c3[nH]c(Nc4c(Cl)cccc4Cl)nc3cc(C(=O)Nc3cccc(c3)C(F)(F)F)c2o1 Show InChI InChI=1S/C24H15Cl2F3N4O2/c1-11-8-14-19-18(31-23(32-19)33-20-16(25)6-3-7-17(20)26)10-15(21(14)35-11)22(34)30-13-5-2-4-12(9-13)24(27,28)29/h2-10H,1H3,(H,30,34)(H2,31,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Limited
Curated by ChEMBL
| Assay Description
Inhibition of mPGES1 in human whole blood assessed as inhibition of LPS-induced PGE2 production measured after 20 to 24 hrs |
Bioorg Med Chem Lett 27: 5131-5138 (2017)
Article DOI: 10.1016/j.bmcl.2017.10.062
BindingDB Entry DOI: 10.7270/Q2JS9T0V |
More data for this
Ligand-Target Pair | |