Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prostaglandin E synthase
(Homo sapiens (Human)) | BDBM50426962
(CHEMBL2325085)Show SMILES Cc1cc2oc(nc2cc1Cl)N1CCC(CC1)C(=O)N[C@H]1CC[C@](C)(O)CC1 |r,wU:23.26,20.22,wD:23.27,(27.31,-32.6,;28.65,-31.83,;29.98,-32.6,;31.32,-31.83,;32.79,-32.31,;33.7,-31.05,;32.79,-29.8,;31.31,-30.28,;29.98,-29.51,;28.65,-30.28,;27.32,-29.51,;35.24,-31.05,;36,-32.39,;37.53,-32.4,;38.31,-31.07,;37.54,-29.73,;36,-29.73,;39.85,-31.07,;40.62,-29.74,;40.61,-32.41,;42.15,-32.42,;42.92,-31.09,;44.47,-31.11,;45.23,-32.45,;46.56,-31.67,;46.57,-33.21,;44.45,-33.77,;42.91,-33.77,)| Show InChI InChI=1S/C21H28ClN3O3/c1-13-11-18-17(12-16(13)22)24-20(28-18)25-9-5-14(6-10-25)19(26)23-15-3-7-21(2,27)8-4-15/h11-12,14-15,27H,3-10H2,1-2H3,(H,23,26)/t15-,21- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human mPGES1 by ELISA |
Bioorg Med Chem Lett 23: 1120-6 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.107 BindingDB Entry DOI: 10.7270/Q26W9CDS |
More data for this Ligand-Target Pair | |
Prostaglandin E synthase
(Homo sapiens (Human)) | BDBM50426962
(CHEMBL2325085)Show SMILES Cc1cc2oc(nc2cc1Cl)N1CCC(CC1)C(=O)N[C@H]1CC[C@](C)(O)CC1 |r,wU:23.26,20.22,wD:23.27,(27.31,-32.6,;28.65,-31.83,;29.98,-32.6,;31.32,-31.83,;32.79,-32.31,;33.7,-31.05,;32.79,-29.8,;31.31,-30.28,;29.98,-29.51,;28.65,-30.28,;27.32,-29.51,;35.24,-31.05,;36,-32.39,;37.53,-32.4,;38.31,-31.07,;37.54,-29.73,;36,-29.73,;39.85,-31.07,;40.62,-29.74,;40.61,-32.41,;42.15,-32.42,;42.92,-31.09,;44.47,-31.11,;45.23,-32.45,;46.56,-31.67,;46.57,-33.21,;44.45,-33.77,;42.91,-33.77,)| Show InChI InChI=1S/C21H28ClN3O3/c1-13-11-18-17(12-16(13)22)24-20(28-18)25-9-5-14(6-10-25)19(26)23-15-3-7-21(2,27)8-4-15/h11-12,14-15,27H,3-10H2,1-2H3,(H,23,26)/t15-,21- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of mPGES1 mediated PGE2 production in LPS-stimulated human whole blood by ELISA |
Bioorg Med Chem Lett 23: 1120-6 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.107 BindingDB Entry DOI: 10.7270/Q26W9CDS |
More data for this Ligand-Target Pair | |